APP Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: RA10797-50, RA10797-100
Citations, Manuals and MSDS Available upon request.
Condition: Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Store at: -20°C/1 year
Recommended Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification Technology: Affinity purification
Alternative Names: APP, A4, AD1, Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II
Background: amyloid beta precursor protein (APP) Homo sapiens This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014],
Applications: WB, IHC-p, IF (paraffin section), ELISA
Species Cross-Reactivity: Human
GeneID (Human): 351
SWISS: P05067
Source: Mouse
Immunogen: Purified recombinant fragment of APP expressed in E. Coli.
Category: Monoclonal
Research Use Only