Atm Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: RA22219-50, RA22219-100
Citations, Manuals and MSDS Available upon request.
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Store at: -20°C/1 year
Recommended Dilutions: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Purification Technology:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Names: ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Background: ATM serine/threonine kinase(ATM) Homo sapiens The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010],
Applications: WB, IHC-p, IF (paraffin section), ELISA
Species Cross-Reactivity: Human, Mouse
Molecular Weight: 350
Protein Molecular Weight (kDa): 350
GeneID (Human): 472
SWISS: Q13315
Source: Rabbit
Immunogen: The antiserum was produced against synthesized peptide derived from human ATM. AA range:1950-1999
Category: Polyclonal
Research Use Only