Bcl-10 Monoclonal Antibody
Size: 50μL, 100μL
Catalogue Numbers: RA10831-50, RA10831-100
Citations, Manuals and MSDS Available upon request.
Background: B-cell CLL/lymphoma 10 (BCL10) Homo sapiens This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
Condition: Purified antibody in PBS containing 0.03% sodium azide.
Storage Instructions: -20°C/1 year
Applications: WB; IHC-p; IF/ICC; FCM; ELISA
Species Cross-Reactivity: Human; Mouse
GeneID (Human): 8915
SWISS: O95999
Source: Mouse
Research Use Only