Bcr (phospho Tyr177) Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA22362-50, RA22362-100
Citations, Manuals and MSDS Available upon request.
Background: BCR, RhoGEF and GTPase activating protein (BCR) Homo sapiens A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Alternative Names: BCR; BCR1; D22S11; Breakpoint cluster region protein; Renal carcinoma antigen NY-REN-26
Applications: WB; ELISA
Species Cross-Reactivity: Human; Mouse
GeneID (Human): 613
Protein MW (KDa): 160
SWISS: P11274
Source: Rabbit
Research Use Only