Caspase 4 (p10, Cleaved-Ala290) Rabbit Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA22725-50, RA22725-100
Citations, Manuals and MSDS Available upon request.
Background: catalytic activity:Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.,PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 1 CARD domain.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit.,tissue specificity:Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.,
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: WB 1:1000-2000 ELISA 1:5000-20000
Alternative Names: Caspase-4 (CASP-4;EC 3.4.22.57;ICE (rel) -II;Protease ICH-2;Protease TX) [Cleaved into: Caspase-4 subunit 1; Caspase-4 subunit 2]
Applications: WB; ELISA
Species Cross-Reactivity: Human; Rat; Mouse
GeneID (Human): 837
Protein MW (KDa): 10 42
SWISS: P49662
Source: Rabbit
Research Use Only