CD299 Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA23012-50, RA23012-100
Citations, Manuals and MSDS Available upon request.
Background: C-type lectin domain family 4 member M (CLEC4M) Homo sapiens This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000
Alternative Names: C-type lectin domain family 4 member M (CD209 antigen-like protein 1;DC-SIGN-related protein;DC-SIGNR;Dendritic cell-specific ICAM-3-grabbing non-integrin 2;DC-SIGN2;Liver/lymph node-specific ICAM-3-grabbing non-integrin;L-SIGN;CD antigen CD299)
Applications: WB; IHC-p; IF (paraffin section) ; ELISA
Species Cross-Reactivity: Human; Mouse; Rat
GeneID (Human): 10332
Protein MW (KDa): 60
SWISS: Q9H2X3
Source: Rabbit
Research Use Only