E2F-1 (Acetyl-K117) Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: RA20985-50, RA20985-100
Citations, Manuals and MSDS Available upon request.
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Store at: -20°C/1 year
Recommended Dilutions: wb dilution 1:2000
Purification Technology:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Names: Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)
Background: E2F transcription factor 1(E2F1) Homo sapiens The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can media
Applications: WB, ELISA
Species Cross-Reactivity: Human:K117, Mouse:K112, Rat:K115
Molecular Weight: 70
Protein Molecular Weight (kDa): 70
GeneID (Human): 1869
SWISS: Q01094
Source: Rabbit
Immunogen: Synthesized Acetyl peptide derived from human E2F-1. at AA range: K117
Category: Polyclonal
Research Use Only