GluR-δ2 Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA25360-50, RA25360-100
Citations, Manuals and MSDS Available upon request.
Background: glutamate ionotropic receptor delta type subunit 2 (GRID2) Homo sapiens The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Alternative Names: GRID2; GLURD2; Glutamate receptor delta-2 subunit; GluR delta-2 subunit
Applications: WB; IF/ICC; ELISA
Species Cross-Reactivity: Human; Mouse; Rat
GeneID (Human): 2895
Protein MW (KDa): 113
SWISS: O43424
Source: Rabbit
Research Use Only