Acetyl-alpha Tubulin -K40 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A24738-20, A24738-100
Citations, Manuals and SDS Available upon request.
Background: Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms: LIS3; TUBA3; B-ALPHA-1; Acetyl-alpha Tubulin -K40
GeneID: 7846
Swiss-Prot: Q71U36
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Calculated Molecular Weight: 50kDa
Observed Molecular Weight: 55kDa
Immunogen: A synthetic acetylated peptide around K40 of human alpha Tubulin(NP_001257328.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cytoskeleton, Microtubules
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Modifications: Acetyl K40
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Cytoskeleton
Positive Samples: Mouse testis, Rat testis
Keywords: LIS3, TUBA3, B-ALPHA-1, Acetyl-alpha Tubulin -K40
Symbol: TUBA1A
Category: Acetylated Antibodies
Research Use Only