ADAMTS5 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A23125-20, A23125-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis.
Synonyms: ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11; ADAMTS5
GeneID: 11096
Swiss-Prot: Q9UNA0
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Calculated Molecular Weight: 102kDa
Observed Molecular Weight: 76kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 601-700 of human ADAMTS5 (NP_008969.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cytoskeleton, Extracellular Matrix, Ubiquitin
Recommended Dilutions: WB: 1:1000 - 1:5000
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Secreted, Extra Cellular Matrix, Extra Cellular Space
Positive Samples: HeLa, Mouse ovary
Keywords: 11096, sc-83186, sc-134952, ADAMTS5, ADAM-TS 11, ADAM-TS 5, ADAM-TS5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADMP-2, ADAM metallopeptidase with thrombospondin type 1 motif 5, A disintegrin and metalloproteinase with thrombospondin motifs 5, a disintegrin and metalloproteinase with thrombospondin motifs 11, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2), aggrecanase-2, Q9UNA0, ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5, Aggrecanase-2, A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 5 (Aggrecanase-2), A Disintegrin And Metalloproteinase With Thrombospondin Motifs 11, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5, EC 3.4.24.-, ADMP2, ADAM-TS11, ADMP 2, ADAM TS5, ADAMTS 5, ADAM TS 5, ADAMTS 11, ADAM TS 11, sc83186, sc 83186, sc134952, sc 134952
Symbol: ADAMTS5
Category: Monoclonal Antibodies
Research Use Only