ASC/TMS1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A22046-20, A22046-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms: ASC; TMS; TMS1; CARD5; TMS-1; ASC/TMS1
GeneID: 29108
Swiss-Prot: Q9ULZ3
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IHC-P
Calculated Molecular Weight: 22kDa
Observed Molecular Weight: 19kDa/22kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 4-110 of human ASC/TMS1 (NP_037390.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Cancer, Tumor biomarkers, Cell Biology Developmental Biology, Apoptosis, Caspases
Recommended Dilutions: WB: 1:2000 - 1:7000 | IHC-P: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Endoplasmic Reticulum, Mitochondrion, Nucleus
Positive Samples: THP-1, U-937, Jurkat, Mouse thymus, Mouse spleen, Rat thymus
Keywords: 29108, sc-33958, sc-30153, ASC, CARD5, hASC, PYCARD, PYD and CARD domain containing, TMS, TMS 1, TMS1, TMS-1, apoptosis-associated speck-like protein containing a CARD, caspase recruitment domain-containing protein 5, target of methylation-induced silencing 1, Q9ULZ3, PYD And CARD Domain Containing, Apoptosis-Associated Speck-Like Protein Containing A CARD, Caspase Recruitment Domain-Containing Protein 5, Target Of Methylation-Induced Silencing 1, PYD And CARD Domain-Containing Protein, Apoptosis-Associated Speck-Like, HASC, ASC / TMS1, MGC10332, sc33958, sc 33958, sc30153, sc 30153, 免疫, 炎症, 天然免疫, 感染, 病毒, 自身免疫, 炎症小体, 焦亡, NLRP3, NLR, ASC/TMS1
Symbol: PYCARD
Category: Monoclonal Antibodies
Research Use Only