CARD11 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9652-20, A9652-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
Synonyms: PPBL; BENTA; BIMP3; IMD11; CARMA1; IMD11A; CARD11
GeneID: 84433
Swiss-Prot: Q9BXL7
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 133kDa
Observed Molecular Weight: 150kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1055-1154 of human CARD11 (Q9BXL7).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Research Areas: Epigenetics Nuclear Signaling, Cancer, Signal Transduction, Cell Biology Developmental Biology, Apoptosis, Caspases, Immunology Inflammation, B Cell Receptor Signaling Pathway, T Cell Receptor Signaling Pathway
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: K-562, Raji, Mouse thymus
Cellular Location: Cytoplasm, Membrane raft
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.