Cardiac Troponin I (TNNI3) Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A21246-20, A21246-100
Citations, Manuals and SDS Available upon request.
Background: Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.
Synonyms: CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; Cardiac Troponin I (TNNI3)
GeneID: 7137
Swiss-Prot: P19429
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IF/ICC
Calculated Molecular Weight: 24kDa
Observed Molecular Weight: 28kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human Cardiac Troponin I (TNNI3) (NP_000354.4).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cytoskeleton, Microfilaments, Stem Cells, Cardiovascular, Angiogenesis, Heart, Contractility
Recommended Dilutions: WB: 1:2000 - 1:10000 | IF/ICC: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cardiac Myofibril, Cytosol, Sarcomere
Positive Samples: Mouse heart
Keywords: 7137, sc-31654, sc-31655, sc-30483, sc-8118, sc-98830, sc-15368, Cardiac troponin I, CMD2A, CMH7, cTnI, RCM1, TNNC1, TNNI3, troponin I type 3 (cardiac), Troponin I, cardiac muscle, CMD1FF, troponin I3, cardiac type, troponin I, cardiomyopathy, dilated 2A (autosomal recessive), P19429, Troponin I3, Cardiac Type, Cardiomyopathy, Dilated 2A (Autosomal Recessive), Troponin I Type 3 (Cardiac), Cardiac Muscle, Cardiac Troponin I, Troponin I Type 3, CTnI, sc31654, sc 31654, sc31655, sc 31655, sc30483, sc 30483, sc8118, sc 8118, sc98830, sc 98830, sc15368, sc 15368, Cardiac Troponin I (TNNI3)
Symbol: TNNI3
Category: Monoclonal Antibodies
Research Use Only