Cardiac Troponin I (TNNI3) Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A21251-20, A21251-100
Citations, Manuals and SDS Available upon request.
Background: Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.
Synonyms: CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; Cardiac Troponin I (TNNI3)
GeneID: 7137
Swiss Prot: P19429
Tested Applications: ELISA, IHC-P, IF/ICC
Reactivity: Human
Calculated Molecular Weight: 24kDa
Observed Molecular Weight: Refer to figures
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human Cardiac Troponin I (TNNI3) (NP_000354.4)
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: IHC-P: 1:100 - 1:500 | IF/ICC: 1:100 - 1:500
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cytoskeleton, Microfilaments, Stem Cells, Cardiovascular, Angiogenesis, Heart, Contractility
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cardiac Myofibril, Cytosol, Sarcomere
Keywords: sc-31654, sc-31655, sc-30483, sc-8118, sc-98830, sc-15368, Cardiac troponin I, CMD2A, CMH7, cTnI, RCM1, TNNC1, TNNI3, troponin I type 3 (cardiac), Troponin I, cardiac muscle, CMD1FF, troponin I3, cardiac type, troponin I, cardiomyopathy, dilated 2A (autosomal recessive), P19429, 7137, sc31654, sc 31654, sc31655, sc 31655, sc30483, sc 30483, sc8118, sc 8118, sc98830, sc 98830, sc15368, sc 15368, Cardiac Troponin I (TNNI3)
Symbol: TNNI3
Category: Monoclonal Antibodies
Research Use Only