Caspase-1 p20 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A23429-20, A23429-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Synonyms: ICE; P45; IL1BC; Caspase-1 p20
GeneID: 834
Swiss-Prot: P29466
Reactivity: Human
Tested Applications: ELISA, WB
Calculated Molecular Weight: 10KDa/29KDa/35KDa/42KDa/45KDa
Observed Molecular Weight: 20-25kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Caspase-1 p20(NP_001244047.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Cancer, Invasion and Metastasis, Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Caspases, Endocrine Metabolism, Immunology Inflammation, Neuroscience, Neurodegenerative Diseases
Recommended Dilutions: WB: 1:1000 - 1:5000
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Cell Membrane
Positive Samples: THP-1, THP-1+TPA+LPS
Keywords: sc-22164, sc-22163, sc-1780, sc-515, sc-622, CASP 1, CASP1, Caspase 1, Caspase 1/p20/p10, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1BC, IL1BCE, Interleukin 1 beta convertase, p10, p20, P45, caspase 1, caspase-1, CASP1 nirs variant 1, IL-1 beta-converting enzyme, IL1B-convertase, apoptosis-related cysteine peptidase, interleukin 1, beta, convertase, interleukin 1-B converting enzyme, P29466, 834, Caspase-1, sc22164, sc 22164, sc22163, sc 22163, sc1780, sc 1780, sc515, sc 515, sc622, sc 622, Caspase-1 p20
Symbol: CASP1
Category: Monoclonal Antibodies
Research Use Only