Caspase-14 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9618-20, A9618-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
Synonyms: ARCI12; Caspase-14
GeneID: 23581
Swiss-Prot: P31944
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 28kDa
Observed Molecular Weight: 17kDa/28kDa/35kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human Caspase-14 (P31944).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Caspases
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: SH-SY5Y, Mouse thymus, A375, Mouse stomach, Rat lung, Rat stomach
Cellular Location: Cytoplasm, Nucleus
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.