Caspase-2 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A4888-20, A4888-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms: ICH1; NEDD2; CASP-2; NEDD-2; PPP1R57; Caspase-2
GeneID: 835
Swiss-Prot: P42575
Reactivity: Human
Calculated Molecular Weight: 51kDa
Observed Molecular Weight: 14kDa/48kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 334-452 of human Caspase-2 (P29594).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Research Areas: Cancer, Invasion and Metastasis, Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Caspases, Mitochondrial Control of Apoptosis, Ubiquitin, Endocrine Metabolism, Immunology Inflammation
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Jurkat, HeLa, 293T
Cellular Location: Cytoplasm, Cytosol, Mitochondrion, Nucleolus, Nucleus,
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.