Caspase-3 p12 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A19664-20, A19664-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Synonyms: CPP32; SCA-1; CPP32B; Caspase-3 p12
GeneID: 836
Swiss-Prot: P42574
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Calculated Molecular Weight: 32kDa
Observed Molecular Weight: 12kDa/30kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 176-277 of human Caspase-3 p12 (P42574).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Caspases, Mitochondrial Control of Apoptosis, Inhibition of Apoptosis, Death Receptor Signaling Pathway, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease
Recommended Dilutions: WB: 1:500 - 1:2000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm
Positive Samples: Mouse liver, NIH/3T3, Rat spleen, Rat liver
Keywords: 836, sc-22139, sc-22140, sc-1224, sc-1226, sc-1225, sc-6138, sc-98785, sc-7148, Apopain, CASP 3, CASP3, Caspase 3, Caspase 3/p17, Caspase3, CPP 32, CPP32, CPP32B, Cysteine protease CPP32, Protein Yama, SCA 1, SREBP cleavage activity 1, Caspase-3, SCA-1, caspase 3, caspase-3, CASP-3, CPP-32, PARP cleavage protease, apopain, apoptosis-related cysteine peptidase, apoptosis-related cysteine protease, cysteine protease CPP32, procaspase3, protein Yama, P42574, Apoptosis-Related Cysteine Peptidase, Apoptosis-Related Cysteine Protease, SREBP Cleavage Activity 1, Cysteine Protease CPP32, PARP Cleavage Protease, EC 3.4.22.56, Procaspase3, Active Caspase 3, active Caspase-3, Caspase-3 p12, active + pro Caspase 3 CPP32B, TNF
Symbol: CASP3
Category: Monoclonal Antibodies
Research Use Only