Caspase-5 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A16733-20, A16733-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
Synonyms: ICH-3; ICEREL-III; ICE(rel)III; Caspase-5
GeneID: 838
Swiss Prot: P51878
Tested Applications: ELISA, WB
Reactivity: Human
Calculated Molecular Weight: 50kDa
Observed Molecular Weight: 35kDa/50kDa/44kDa
Immunogen: Recombinant Protein corresponding to a sequence within amino acids 140-250 of human Caspase-5 (NP_001129584).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Caspases
Positive Samples: THP-1, THP-1+TPA+LPS
Cellular Location: Cytoplasm, Cytosol, NLRP1 inflammasome Complex
Keywords: 838, CASP5, ICE(rel)III, ICEREL-III, ICH-3, caspase 5, caspase-5, CASP-5, ICE(rel)-III, TY protease, apoptosis-related cysteine peptidase, apoptosis-related cysteine protease, protease ICH-3, protease TY, P51878, Caspase 5, Apoptosis-Related Cysteine Peptidase, Apoptosis-Related Cysteine Protease, Protease ICH-3, Protease TY, ICE(Rel)-III, EC 3.4.22.58, ICE(Rel)III, TY Protease, Caspase-5, ICH3, 免疫, 炎症, 天然免疫, 感染, 病毒, 自身免疫, 炎症小体, 焦亡, NLRP3, NLR
Symbol: CASP5
Category: Polyclonal Antibodies
Research Use Only