Caspase-9 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A4919-20, A4919-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.
Synonyms: MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; Caspase-9
GeneID: 842
Swiss-Prot: P55211
Reactivity: Human
Calculated Molecular Weight: 46kDa
Observed Molecular Weight: 47kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Caspase-9 (P55211).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Caspases, Mitochondrial Control of Apoptosis, Inhibition of Apoptosis, Death Receptor Signaling Pathway, Immunology Inflammation, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Jurkat, 293T
Cellular Location: apoptosome, Cytoplasm, Cytosol, Mitochondrion, Nucleus,
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.