Cathepsin L Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A23375-20, A23375-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.
Synonyms: MEP; CATL; CTSL1; Cathepsin L
GeneID: 1514
Swiss-Prot: P07711
Reactivity: Human
Tested Applications: ELISA, WB, IHC-P
Calculated Molecular Weight: 38kDa
Observed Molecular Weight: 42kDa
Immunogen: Recombinant protein of human Cathepsin L
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cell Adhesion, Cytoskeleton, Extracellular Matrix, Neuroscience
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Lysosome,
Positive Samples: A-549, U-118MG
Keywords: sc-6500, sc-6498, sc-10778, sc-25537, cathepsin L1, CATL, CTSL, CTSL1, Major excreted protein, MEP, cathepsin L, major excreted protein, P07711, 1514, sc6500, sc 6500, sc6498, sc 6498, sc10778, sc 10778, sc25537, sc 25537, FLJ31037, Cathepsin L
Symbol: CTSL
Category: Monoclonal Antibodies
Research Use Only