Caveolin-1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A22417-20, A22417-100
Citations, Manuals and SDS Available upon request.
Background: The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
Synonyms: CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085; Caveolin-1
GeneID: 857
Swiss-Prot: Q03135
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IHC-P, IF/ICC, IP
Calculated Molecular Weight: 20kDa
Observed Molecular Weight: 20-25kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human Caveolin-1 (NP_001744.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Protein phosphorylation, Cancer, Tumor biomarkers, Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Cell Adhesion, Endocrine Metabolism, Lipid Metabolism, Cholesterol Metabolism, Insulin Receptor Signaling Pathway, Cardiovascular, Hypoxia, Lipids
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200 | IP: 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cell Membrane, Golgi Apparatus Membrane, Membrane, Membrane raft, Peripheral Membrane Protein, Caveola
Positive Samples: HeLa, A549, Mouse lung, Mouse heart, Rat lung, Rat heart
Keywords: 857, sc-894, sc-7875, BSCL3, CAV, CAV1, Caveolin 1, Caveolin-1, CGL3, MSTP085, VIP21, LCCNS, PPH3, caveolin 1, caveolin-1, caveolae protein, 22kDa, cell growth-inhibiting protein 32, Q03135, Caveolae Protein, 22kD, Cell Growth-Inhibiting Protein 32, caveolin-1caveolin 1, 22kDacell growth-inhibiting protein 32, Caveolin-1
Symbol: CAV1
Category: Monoclonal Antibodies
Research Use Only