CBS Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A11612-20, A11612-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene.
Synonyms: CBSL; HIP4; CBS
GeneID: 875
Swiss Prot: P35520
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 61kDa
Observed Molecular Weight: 61kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 400-551 of human CBS (P35520).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Amino acid metabolism
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HepG2, MCF7, Mouse liver, Mouse kidney, Rat liver
Cellular Location: Cytoplasm, Nucleus
Keywords: CBS, HIP4, cystathionine-beta-synthase, cystathionine beta-synthase|beta-thionase|methylcysteine synthase|serine sulfhydrase, P35520
Symbol: CBS
Category: Monoclonal Antibodies
Research Use Only