References
JOURNAL OF COLLOID AND INTERFACE SCIENCE
DDG is a non-ionic amphiphilic detergent / surfactant with a diglucose polar group and decyl chain.
N-(2-methyl-1,3-bis(O-β-D-Glucose)propan-2-yl)-3-(decylthio)propanamide
Information
Compound name: DDG
Catalogue number: DDG_100MG, DDG_250MG,
Molec. Formula: C29H55NO13S
CAS: nd
MW: 657.8 g/mol
pKa: na
Percent Composition: C, 52.95; H, 8.43; N, 2.13; O, 31.62; S, 4.87
Physical state: White powder
Purity (HPLC, 214nm): ≤95%
Retention time (RP18 HPLC)b: tR = 14.6 min
CMC: >0.54 mM
Exact mass: 657.3394
Stability: Store in <-20°C freezer for up to one year
Solubility Structure: Soluble in water (27mM), methanol and DMSO
Calixar’s DDG is in a powder application and is used in an aqueous solution or buffer. DDG can be coupled with biological elements (biological membranes).
Our clients use DDG to help create lipid detergents, mixed micelles, and protein detergent micelles. DDG empowers clients to extract, to solubilize and to stabilize native and functional membrane proteins.
DDG is a very moderate detergent used to extract, solubilize and stabilize native membrane proteins non-ionically. Consequently, it is not sensitive to ionic strength or pH variations which are ideal to extract, to solubilize and to stabilize specific membrane proteins of exceptional medical relevance.
CALIXAR’s DDG is non-ionic and hence is not sensitive to ionic strengths or pH variations. It is well conformed to extract, to solubilize and to stabilize specific membrane proteins.
CALIXAR’s DDG extract high-quality membrane proteins used for research, drug discovery including structural studies and are adapted for use in pharmaceutical, biotechnology companies, as well as for academic teams (biochemists, structural biologists, pharmacologists, virologists) that are involved in the life science fields.
For Any Life Science Project
- Antibodies (including nanobodies, scaffold proteins, aptamers)
- Small molecules
- 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
- Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
- Antibody discovery (Immunization and display technologies)
- Clinical stage
ACS PUBLICATIONS
Glucose-Based Surfactants with Hydrogenated, Fluorinated, or Hemifluorinated Tails: Synthesis and Comparative Physical-Chemical Characterization
Abla M et al. 2008