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DDG Reagent

DDG Reagent

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DDG is a non-ionic amphiphilic detergent / surfactant with a diglucose polar group and decyl chain.

N-(2-methyl-1,3-bis(O-β-D-Glucose)propan-2-yl)-3-(decylthio)propanamide

 

Compound name: DDG

Catalogue number: DDG_100MG, DDG_250MG,

Molec. Formula: C29H55NO13S

CAS: nd

MW: 657.8 g/mol

pKa: na​

Percent Composition: C, 52.95; H, 8.43; N, 2.13; O, 31.62; S, 4.87

Physical state: White powder

Purity (HPLC, 214nm): ≤95%

Retention time (RP18 HPLC)b: tR = 14.6 min

CMC: >0.54 mM

Exact mass​: 657.3394

Stability: Store in <-20°C freezer for up to one year

Solubility Structure: Soluble in water (27mM), methanol and DMSO

 

 

CALIXAR employs a unique & tailor-made method

Calixar’s DDG is in a powder application and is used in an aqueous solution or buffer. DDG can be coupled with biological elements (biological membranes).

Our clients use DDG to help create lipid detergents, mixed micelles, and protein detergent micelles. DDG empowers clients to extract, to solubilize and to stabilize native and functional membrane proteins.

DDG is a very moderate detergent used to extract, solubilize and stabilize native membrane proteins non-ionically. Consequently, it is not sensitive to ionic strength or pH variations which are ideal to extract, to solubilize and to stabilize specific membrane proteins of exceptional medical relevance.

  

CALIXAR’s DDG is non-ionic and hence is not sensitive to ionic strengths or pH variations. It is well conformed to extract, to solubilize and to stabilize specific membrane proteins.

 

CALIXAR’s DDG extract high-quality membrane proteins used for research, drug discovery including structural studies and are adapted for use in pharmaceutical, biotechnology companies, as well as for academic teams (biochemists, structural biologists, pharmacologists, virologists) that are involved in the life science fields.

 

  • Antibodies (including nanobodies, scaffold proteins, aptamers)
  • Small molecules
  • 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
  • Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
  • Antibody discovery (Immunization and display technologies)
  • Clinical stage

 

References

JOURNAL OF COLLOID AND INTERFACE SCIENCE

Micellar and biochemical properties of a propyl-ended fluorinated surfactant designed for membrane-protein study

Abla M et al. 2015

 
 

INSTITUT DE BIOLOGIE STRUCTURALE

Structure and Stability of Integral Membrane Protein and Phage Assemblies

Breyton C et al. 2013

READ MORE

 

ACS PUBLICATIONS

Glucose-Based Surfactants with Hydrogenated, Fluorinated, or Hemifluorinated Tails: Synthesis and Comparative Physical-Chemical Characterization

Abla M et al. 2008

READ MORE