Dynactin 1 (N-term) mouse mAb
Sizes: 50µl, 100µl
Catalogue Numbers: RA11107-50, RA11107-100
Citations, Manuals and MSDS Available upon request.
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Store at: -20°C/1 year
Recommended Dilution: wb 1:500
Purification Technology: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Alternative Names: 150 kDa dynein associated polypeptide, 150 kDa dynein-associated polypeptide, DAP 150, DAP-150, DAP150, DCTN 1, DCTN1, DCTN1_HUMAN, DP 150, DP-150, DP150, Dynactin 1 (p150 Glued (Drosophila) homolog), dynactin 1 (p150 glued homolog Drosophila), Dynactin 1, Dynactin subunit 1, Dynactin1, HMN7B, p135, p150 Glued (Drosophila) homolog, p150 glued, p150 glued homolog, p150(GLUED) DROSOPHILA HOMOLOG OF, p150-glued, p150glued.
Background: dynactin subunit 1 (DCTN1) Homo sapiens This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [
Applications: WB, IP
Species Cross-Reactivity: Human
GeneID (Human): 1639
SWISS: Q14203
Source: Mouse
Immunogen: Purified recombinant Dynactin 1 protein fragments expressed in E.coli
Category: Monoclonal
Research Use Only