E-Cadherin Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A22333-20, A22333-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
Synonyms: UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324; E-Cadherin
GeneID: 999
Swiss-Prot: P12830
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IF/ICC
Calculated Molecular Weight: 97kDa
Observed Molecular Weight: 135kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 700-800 of human E-Cadherin (NP_004351.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Cancer, Invasion and Metastasis, Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Cell Cycle, Centrosome, Cell Adhesion, Cadherins, Tight Junctions, Cytoskeleton, Wnt ��-Catenin Signaling Pathway, Immunology Inflammation, CDs, Neuroscience, Calcium Signaling
Recommended Dilutions: WB: 1:500 - 1:1000 | IF/ICC: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cell Junction, Cell Membrane, Endosome, Golgi Apparatus, Single-pass Type I Membrane Protein, Trans-Golgi Network
Positive Samples: HCT 116, MCF7, Mouse lung, Mouse liver, Rat kidney
Keywords: 999, sc-1500, sc-31020, sc-31021, sc-1499, sc-7870, Arc 1, Cadherin 1, CAM 120/80, CD324, CDH1, CDHE, E cadherin, ECAD, E-cadherin, Epithelial cadherin, LCAM, UVO, Uvomorulin, Arc-1, cadherin 1, cadherin-1, E-cadherin 1, E-cadherin (epithelial), type 1, calcium-dependent adhesion protein, epithelial, cell-CAM 120/80, epithelial cadherin, uvomorulin, P12830, Cdh1, Type 1, E-Cadherin (Epithelial), Epithelial Cadherin, E-Cadherin, Calcium-Dependent Adhesion Protein, Epithelial, Cell-CAM 120/80, CD324 Antigen, E-Cadherin 1, Cadherin-1, BCDS1, Arc1, sc1500, sc 1500, sc31020, sc 31020, sc31021, sc 31021, sc1499, sc 1499, sc7870, sc 7870, marker, Cell junction, Cell junction marker
Symbol: CDH1
Category: Monoclonal Antibodies
Research Use Only