pan 14-3-3 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A23829-20, A23829-100
Citations, Manuals and SDS Available upon request.
Background: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.
Synonyms: 1C5; HS1; 14-3-3; GW128; YWHAA; KCIP-1; HEL-S-1; HEL4; YWHAD; HEL-S-3; POPCHAS; HEL-S-93; 14-3-3-zeta; pan 14-3-3
GeneID: 10971/7529/7532/7531/7534/7533/2810
Swiss-Prot: P27348/P31946/P61981/P62258/P63104/Q04917/P31947
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IF/ICC
Calculated Molecular Weight: 27kDa/28KDa/29KDa
Observed Molecular Weight: 30kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids human 1-100 of human pan 14-3-3 (NP_006817.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Signal transduction, Checkpoint control, Apoptotic, Nutrient-sensing pathways
Recommended Dilutions: WB: 1:1000 - 1:5000 | IF/ICC: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytosol, Melanosome, ExtraCellular
Positive Samples: Jurkat, HeLa, 293F, NIH/3T3, H-4-11-E
Keywords: 1C5, HS1, 14-3-3, GW128, YWHAA, KCIP-1, HEL-S-1, HEL4, YWHAD, HEL-S-3, POPCHAS, HEL-S-93, 14-3-3-zeta, pan 14-3-3
Symbol: YWHAQ/YWHAB/YWHAG/YWHAE/YWHAZ/YWHAH/SFN
Category: Monoclonal Antibodies
Research Use Only