PAX5 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9607-20, A9607-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms: ALL3; BSAP; PAX-5; PAX5
GeneID: 5079
Swiss-Prot: Q02548
Reactivity: Human
Calculated Molecular Weight: 42kDa
Observed Molecular Weight: 45kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PAX5 (Q02548).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P, IP
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:100 - 1:500 | IHC-P: 1:50 - 1:200 | IP: 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Neuroscience
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Raji cells
Cellular Location: Nuclear,
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.