PEN2/PSENEN Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A8678-20, A8678-100
Citations, Manuals and SDS Available upon request.
Background: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants.
Synonyms: PEN2; PEN-2; MDS033; ACNINV2; MSTP064; PEN2/PSENEN
GeneID: 55851
Swiss-Prot: Q9NZ42
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 12kDa
Observed Molecular Weight: 14kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-101 of human PEN2/PSENEN (NP_758844.1)
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IF/ICC: 1:50 - 1:200
Research Areas: Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, ESC Pluripotency and Differentiation, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease, Neurodegenerative Diseases Markers
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: 293T, A549, SH-SY5Y, Mouse kidney, Rat lung
Cellular Location: Endoplasmic Reticulum, Golgi Apparatus, Mitochondrion, Plasma Membrane, preSynaptic Membrane,
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.