PERK Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A21255-20, A21255-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Synonyms: PEK; WRS; PERK
GeneID: 9451
Swiss-Prot: Q9NZJ5
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Calculated Molecular Weight: 125kDa
Observed Molecular Weight: 140kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 580-720 of human PERK (NP_004827.4).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Epigenetics Nuclear Signaling, Translation Control, Signal Transduction, Kinase, Serine threonine kinases, Cell Biology Developmental Biology, Apoptosis, Endocrine Metabolism, Endocrine and metabolic diseases, Diabetes, Obesity, Neuroscience, Neurodegenerative Diseases
Recommended Dilutions: WB: 1:500 - 1:1000
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Endoplasmic Reticulum Membrane, Single-pass Type I Membrane Protein
Positive Samples: 293T, K-562, NIH/3T3, PC-12
Keywords: sc-9481, sc-9479, sc-13073, EIF2AK3, HRI, HsPEK, Pancreatic eIF2 alpha kinase, PEK, PERK, WRS, eukaryotic translation initiation factor 2 alpha kinase 3, eukaryotic translation initiation factor 2-alpha kinase 3, PRKR-like endoplasmic reticulum kinase, pancreatic EIF2-alpha kinase, Q9NZJ5, 9451, DKFZp781H1925, sc9481, sc 9481, sc9479, sc 9479, sc13073, sc 13073
Symbol: EIF2AK3
Category: Monoclonal Antibodies
Research Use Only