PFKFB3 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A22317-20, A22317-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: PFK2; IPFK2; iPFK-2; PFKFB3
GeneID: 5209
Swiss-Prot: Q16875
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IHC-P
Calculated Molecular Weight: 57kDa/58kDa/59kDa/60kDa
Observed Molecular Weight: 60kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 400-500 of human PFKFB3 (NP_004557.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Endocrine Metabolism, Carbohydrate metabolism, AMPK Signaling Pathway, Warburg Effect
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytosol, Nucleoplasm
Positive Samples: HeLa, Mouse brain
Keywords: PFKFB3, IPFK2, PFK2, iPFK-2, 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3, 6-bisphosphatase 3|6-phosphofructo-2-kinase/ fructose-2, 6-bisphosphatase|6PF-2-K/Fru-2, 6-P2ase 3|6PF-2-K/Fru-2, 6-P2ase brain/placenta-type isozyme|PFK/FBPase 3|fructose-6-phosphate, 2-kinase/fructose-2, 6-bisphosphatase|inducible 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase|renal carcinoma antigen NY-REN-56, Q16875
Symbol: PFKFB3
Category: Monoclonal Antibodies
Research Use Only