Phospho-ATR-S428 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: AP1358-20, AP1358-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
Synonyms: FRP1; MEC1; SCKL; FCTCS; SCKL1; Phospho-ATR-S428
GeneID: 545
Swiss-Prot: Q13535
Reactivity: Human
Calculated Molecular Weight: 301kDa
Observed Molecular Weight: 300kDa
Immunogen: A synthetic phosphorylated peptide around S428 of human ATR (NP_001175.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:1000 - 1:5000
Research Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones, DNA Damage Repair, Protein phosphorylation, Cancer, Tumor suppressors, Signal Transduction, Kinase, Serine threonine kinases, Cell Biology Developmental Biology, Apoptosis, Mitochondrial Control of Apoptosis, Cell Cycle, Cell Cycle Control-G1 S Checkpoint, Cell Cycle Control-G2 M DNA Damage Checkpoint
Modifications: Phospho S428
Conjugate: Unconjugated
Positive Samples: 293T+UV
Cellular Location: Chromosome, Nucleus, PML Body
Category: Phosphorylated Antibodies
Citations, Manuals and SDS Available upon request.