Phospho-c-Myc-T58/S62 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: AP0988-20, AP0988-100
Citations, Manuals and SDS Available upon request.
Background: This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.
Synonyms: MRTL; MYCC; c-Myc; bHLHe39; Phospho-c-Myc-T58/S62
GeneID: 4609
Swiss-Prot: P01106
Reactivity: Rat
Calculated Molecular Weight: 51kDa
Observed Molecular Weight: 51kDa
Immunogen: A synthetic phosphorylated peptide around T58 & S62 of human c-Myc (P01106).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Protein phosphorylation, Cancer, Tumor biomarkers, Signal Transduction, MAPK-Erk Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Cell Cycle, Cell differentiation, Cell Cycle Control-G1 S Checkpoint, Endocrine Metabolism, Warburg Effect, Immunology Inflammation, Jak-Stat-IL-6 Receptor Signaling Pathway, Stem Cells
Modifications: Phospho T58/S62
Conjugate: Unconjugated
Positive Samples: C6
Cellular Location: Nucleus, Nucleolus, Nucleoplasm
Category: Phosphorylated Antibodies
Citations, Manuals and SDS Available upon request.