Phospho-STING/TMEM173-S366 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: AP1369-20, AP1369-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.
Synonyms: ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; TMEM173; STING-beta; Phospho-STING/TMEM173-S366
GeneID: 340061
Swiss-Prot: Q86WV6
Reactivity: Human
Calculated Molecular Weight: 42kDa
Observed Molecular Weight: 33kDa/40kDa
Immunogen: A synthetic phosphorylated peptide around S366 of human STING1 (NP_938023.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Epigenetics Nuclear Signaling, Cancer, Immunology Inflammation, Cytokines, Cell Intrinsic Innate Immunity Signaling Pathway
Modifications: Phospho S366
Conjugate: Unconjugated
Positive Samples: THP-1
Cellular Location: Cell Membrane, Cytoplasm, Endoplasmic Reticulum Membrane, Mitochondrion Outer Membrane, Multi-pass Membrane Protein, Perinuclear Region
Category: Phosphorylated Antibodies
Citations, Manuals and SDS Available upon request.