PKC alpha Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A11107-20, A11107-100
Citations, Manuals and SDS Available upon request.
Background: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
Synonyms: AAG6; PKCA; PRKACA; PKCI+/-; PKCalpha; PKC-alpha; PKC alpha
GeneID: 5578
Swiss Prot: P17252
Tested Applications: ELISA, WB, IHC-P, IP
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 77kDa
Observed Molecular Weight: 76kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 573-672 of human PKC alpha (P17252).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200 | IP: 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Research Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones, Protein phosphorylation, Cancer, Signal Transduction, G protein signaling, G-Protein-Coupled Receptors Signaling to MAPK Erk, Kinase, Serine threonine kinases, mTOR Signaling Pathway, ErbB-HER Signaling Pathway, MAPK-Erk Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Mitochondrial Control of Apoptosis, Inhibition of Apoptosis, Cell Adhesion, Cytoskeleton, Microtubules, Actins, TGF-b-Smad Signaling Pathway, Endocrine Metabolism, Immunology Inflammation, B Cell Receptor Signaling Pathway, Neuroscience, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease, Neurodegenerative Diseases Markers, Cardiovascular, Heart, Hypertrophy
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, Jurkat, Mouse brain, Mouse lung, Rat brain
Cellular Location: Cell Membrane, Cytoplasm, Mitochondrion Membrane, Nucleus, Peripheral Membrane Protein,
Keywords: 5578, sc-10800, sc-208, AAG6, PKC A, PKC alpha, PKCA, PRKACA, PRKCA, Protein kinase C alpha type, protein kinase C, alpha, PKC-alpha, protein kinase C alpha, protein kinase C alpha type, PKC-A, aging-associated gene 6, P17252, Protein Kinase C Alpha, PKC-Alpha, Protein Kinase C Alpha Type, Aging-Associated Gene 6, Protein Kinase C, Alpha, EC 2.7.11.13, PKCalpha, sc10800, sc 10800, sc208, sc 208
Symbol: PRKCA
Category: Monoclonal Antibodies
Research Use Only