PKC-beta Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A21241-20, A21241-100
Citations, Manuals and SDS Available upon request.
Background: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms: PKCB; PRKCB1; PRKCB2; PKCI(2); PKCbeta; PKC-beta
GeneID: 5579
Swiss-Prot: P05771
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IHC-P
Calculated Molecular Weight: 77kDa
Observed Molecular Weight: 80kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 260-340 of human PKC-beta (NP_997700.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Protein phosphorylation, Signal Transduction, G protein signaling, G-Protein-Coupled Receptors Signaling to MAPK Erk, Kinase, ErbB-HER Signaling Pathway, MAPK-Erk Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Mitochondrial Control of Apoptosis, Inhibition of Apoptosis, TGF-b-Smad Signaling Pathway, Immunology Inflammation, B Cell Receptor Signaling Pathway
Recommended Dilutions: WB: 1:2000 - 1:20000 | IHC-P: 1:100 - 1:500
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Membrane, Nucleus, Peripheral Membrane Protein
Positive Samples: Jurkat, SK-MEL-28, Mouse brain, Rat brain
Keywords: 5579, sc-210, sc-209, PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2, protein kinase C beta, protein kinase C beta type, PKC-B, protein kinase C, beta 1 polypeptide, P05771, Protein Kinase C Beta, PKC-Beta, Protein Kinase C, Beta 1 Polypeptide, Protein Kinase C Beta Type, Beta 1, Beta, EC 2.7.11.13, PKCbeta, PKC beta, sc210, sc 210, sc209, sc 209, PKC B, Protein kinase C beta type, beta
Symbol: PRKCB
Category: Monoclonal Antibodies
Research Use Only