PKC gamma Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9565-20, A9565-100
Citations, Manuals and SDS Available upon request.
Background: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene.
Synonyms: PKCC; PKCG; SCA14; PKCI(3); PKCgamma; PKC-gamma; PKC gamma
GeneID: 5582
Swiss-Prot: P05129
Reactivity: Mouse, Rat
Calculated Molecular Weight: 78kDa
Observed Molecular Weight: 78kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 604-697 of human PKC gamma (P05129).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Epigenetics Nuclear Signaling, Signal Transduction, G protein signaling, G-Protein-Coupled Receptors Signaling to MAPK Erk, Kinase, Serine threonine kinases, ErbB-HER Signaling Pathway, MAPK-Erk Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Mitochondrial Control of Apoptosis, Inhibition of Apoptosis, TGF-b-Smad Signaling Pathway, Immunology Inflammation, B Cell Receptor Signaling Pathway, Neuroscience, Neurodegenerative Diseases
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Mouse brain, Rat brain
Cellular Location: Cell Junction, Cell Membrane, Cell Projection, Cytoplasm, Peripheral Membrane Protein, Dendrite, Perinuclear Region, Synapse, Synaptosome
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.