PKM2-specific Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A22408-20, A22408-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.
Synonyms: PK3; TCB; p58; OIP3; PKM2; CTHBP; THBP1; HEL-S-30; PKM2-specific
GeneID: 5315
Swiss-Prot: P14618
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Calculated Molecular Weight: 58kDa
Observed Molecular Weight: 60kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 380-480 of human PKM2-specific (NP_002645.3).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Epigenetics Nuclear Signaling, RNA Binding, Protein phosphorylation, Cancer, Tumor biomarkers, Signal Transduction, Endocrine Metabolism, Carbohydrate metabolism, Warburg Effect
Recommended Dilutions: WB: 1:500 - 1:1000
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Nucleus
Positive Samples: HeLa, HepG2, NIH/3T3, C6, Mouse skeletal muscle(negative), Mouse heart(negative), Rat skeletal muscle(negative), Rat heart(negative)
Keywords: 5315, sc-65177, sc-65178, sc-65176, sc-135048, sc-292640, CTHBP, OIP 3, OIP3, Opa interacting protein 3, p58, PK2, PK3, PKM, PKM1, PK-M1, PKM1 pyruvate kinase, muscle, Pyruvate kinase 2/3, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle isozyme, TCB, THBP1, Tumor M2 PK, PKM2, PKM2 pyruvate kinase, PK-M2, HEL-S-30, pyruvate kinase, pyruvate kinase PKM, OIP-3, OPA-interacting protein 3, PK, muscle type, cytosolic thyroid hormone-binding protein, epididymis secretory protein Li 30, pyruvate kinase 2/3, pyruvate kinase isozymes M1/M2, pyruvate kinase muscle isozyme, thyroid hormone-binding protein 1, thyroid hormone-binding protein, cytosolic, tumor M2-PK, P14618, Pyruvate Kinase M1/2, Cytosolic Thyroid Hormone-Binding Protein, Thyroid Hormone-Binding Protein 1, Pyruvate Kinase Muscle Isozyme, Pyruvate Kinase, Muscle, Pyruvate Kinase 2/3, Tumor M2-PK, P58, Thyroid Hormone-Binding Protein, Cytosolic, Epididymis Secretory Protein Li 30, Pyruvate Kinase Isozymes M1/M2, OPA-Interacting Protein 3, Opa-Interacting Protein 3, Pyruvate Kinase PKM, Muscle Type, EC 2.7.1.40, pyruvate kinase PKMOIP-3OPA-interacting protein 3PK, muscle typecytosolic thyroid hormone-binding proteinepididymis secretory protein Li 30p58pyruvate kinase 2/3pyruvate kinase isozymes M1/M2pyruvate kinase muscle isozymethyroid hormone-binding protein 1thyroid hormone-binding protein, cytosolictumor M2-PK, PKM2-specific
Symbol: PKM
Category: Monoclonal Antibodies
Research Use Only