PKR/EIF2AK2 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A19545-20, A19545-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses.
Synonyms: PKR; PRKR; DYT33; LEUDEN; EIF2AK1; PPP1R83; PKR/EIF2AK2
GeneID: 5610
Swiss-Prot: P19525
Reactivity: Human
Tested Applications: ELISA, WB
Calculated Molecular Weight: 62kDa
Observed Molecular Weight: 70kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 450-551 of human PKR/EIF2AK2 (P19525).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Epigenetics Nuclear Signaling, Translation Control, Protein phosphorylation, Signal Transduction, Kinase, Serine threonine kinases, Cell Biology Developmental Biology, Apoptosis, Autophagy, Immunology Inflammation
Recommended Dilutions: WB: 1:500 - 1:1000
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Nucleus, Perinuclear Region
Positive Samples: HT-29, MCF7, SH-SY5Y, HepG2
Keywords: 5610, sc-709, sc-707, sc-708, eIF 2A protein kinase 2, EIF2AK1, EIF2AK2, P1/eIF 2A protein kinase, p68 kinase, PKR, PRKR, Protein kinase RNA activated, PPP1R83, eukaryotic translation initiation factor 2 alpha kinase 2, interferon-induced, double-stranded RNA-activated protein kinase, P1/eIF-2A protein kinase, double stranded RNA activated protein kinase, eIF-2A protein kinase 2, interferon-inducible elF2alpha kinase, protein kinase R, protein kinase, interferon-inducible double stranded RNA dependent, protein phosphatase 1, regulatory subunit 83, tyrosine-protein kinase EIF2AK2, P19525, Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2, Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent, Protein Phosphatase 1, Regulatory Subunit 83, Tyrosine-Protein Kinase EIF2AK2, P1/EIF-2A Protein Kinase, EIF-2A Protein Kinase 2, Protein Kinase R, P68 Kinase, Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase, Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2, Interferon-Inducible RNA-Dependent Protein Kinase, Double Stranded RNA Activated Protein Kinase, Interferon-Inducible ElF2alpha Kinase, Protein Kinase RNA-Activated, EC 2.7.11.1, EC 2.7.10.2, Eif2ak2, PKR/EIF2AK2
Symbol: EIF2AK2
Category: Monoclonal Antibodies
Research Use Only