PML Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A19646-20, A19646-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms: MYL; RNF71; PP8675; TRIM19; PML
GeneID: 5371
Swiss-Prot: P29590
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Calculated Molecular Weight: 98kDa
Observed Molecular Weight: 68-120kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PML (P29590).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Cancer, Cell Biology Developmental Biology, Apoptosis, Ubiquitin, Ubiquitin-Proteasome Signaling Pathway, Endocrine Metabolism, Cardiovascular, Angiogenesis
Recommended Dilutions: WB: 1:500 - 1:1000
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Cytoplasmic Side, Early Endosome Membrane, Endoplasmic Reticulum Membrane, Nucleus, PML Body, Peripheral Membrane Protein, Nucleolus, Nucleoplasm
Positive Samples: HeLa, A549, 293T
Keywords: 5371, sc-9862, sc-9863, sc-5621, MYL, PML, PP8675, promyelocytic leukemia, RING finger protein 71, RNF71, TRIM19, protein PML, PML/RARA fusion, probable transcription factor PML, promyelocytic leukemia protein, inducer of, tripartite motif protein TRIM19, tripartite motif-containing protein 19, P29590, Promyelocytic Leukemia, Tripartite Motif-Containing Protein 19, Promyelocytic Leukemia Protein, RING Finger Protein 71, Inducer Of, Probable Transcription Factor PML, Tripartite Motif Protein TRIM19, PML/RARA Fusion, Protein PML, PML （isoform 5）, PML(isoform5)
Symbol: PML
Category: Monoclonal Antibodies
Research Use Only