PMS2 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A4577-20, A4577-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.
Synonyms: MLH4; PMS-2; PMSL2; HNPCC4; LYNCH4; MMRCS4; PMS2CL; PMS2
GeneID: 5395
Swiss Prot: P54278
Tested Applications: ELISA, WB
Reactivity: Human
Calculated Molecular Weight: 96kDa
Observed Molecular Weight: 110kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PMS2 (P54278).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Jurkat, SH-SY5Y, HeLa
Cellular Location: Nucleus
Keywords: PMS2, HNPCC4, MLH4, PMS2CL, PMSL2, PMS1 homolog 2, mismatch repair system component, mismatch repair endonuclease PMS2|DNA mismatch repair protein PMS2|PMS1 homolog 2, mismatch repair protein|PMS1 protein homolog 2|PMS2 postmeiotic segregation increased 2|postmeiotic segregation increased 2 nirs variant 6, P54278
Symbol: PMS2
Category: Monoclonal Antibodies
Research Use Only