PON1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A3441-20, A3441-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7.
Synonyms: ESA; PON; MVCD5; PON1
GeneID: 5444
Swiss-Prot: P27169
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 40kDa
Observed Molecular Weight: 40kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PON1 (P27169).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Endocrine Metabolism, Lipid Metabolism, Drug metabolism, Endocrine and metabolic diseases, Diabetes, Neuroscience, Neurodegenerative Diseases, Dopamine Signaling in Parkinson's Disease, Cardiovascular, Lipids
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Mouse liver, HepG2
Cellular Location: Secreted, Extra Cellular Space
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.