PPP1CA Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A24288-20, A24288-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: PP1A; PP-1A; PPP1A; PP1alpha; PPP1CA
GeneID: 5499
Swiss-Prot: P62136
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Calculated Molecular Weight: 38kDa
Observed Molecular Weight: 38kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 230-330 of human PPP1CA(NP_002699.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones, Translation Control, Protein phosphorylation, Cancer, Signal Transduction, G protein signaling, Kinase, Serine threonine kinases, MAPK-Erk Signaling Pathway, Endocrine Metabolism, Lipid Metabolism, Insulin Receptor Signaling Pathway, Neuroscience, Neurodegenerative Diseases, Dopamine Signaling in Parkinson's Disease
Recommended Dilutions: WB: 1:1000 - 1:5000 | IHC-P: 1:100 - 1:500 | IF/ICC: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Nucleus, Nucleolus, Nucleoplasm
Positive Samples: Jurkat, MCF7, NIH/3T3, C6
Keywords: 5499, sc-6105, sc-6104, sc-443, PPP1CA, PP-1A, PP1A, PP1alpha, PPP1A, protein phosphatase 1 catalytic subunit alpha, serine/threonine-protein phosphatase PP1-alpha catalytic subunit, protein phosphatase 1, catalytic subunit, alpha isoform, alpha isozyme, serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit, testicular tissue protein Li 155, P62136, Protein Phosphatase 1 Catalytic Subunit Alpha, Protein Phosphatase 1, Catalytic Subunit, Alpha Isoform, Alpha Isozyme, Serine/Threonine Protein Phosphatase PP1-Alpha 1 Catalytic Subunit, Serine/Threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit, Testicular Tissue Protein Li 155, EC 3.1.3.16, MGC15877, MGC1674, PP 1A, sc6105, sc 6105, sc6104, sc 6104, sc443, sc 443
Symbol: PPP1CA
Category: Monoclonal Antibodies
Research Use Only