PSMB9/LMP2 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9549-20, A9549-100
Citations, Manuals and SDS Available upon request.
Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit.
Synonyms: LMP2; PRAAS3; PSMB6i; RING12; beta1i; PSMB9/LMP2
GeneID: 5698
Swiss-Prot: P28065
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 23kDa
Observed Molecular Weight: 21kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 125-219 of human PSMB9/LMP2 (P28065).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IHC-P: 1:50 - 1:200
Research Areas: Cell Biology Developmental Biology, Ubiquitin
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Raji, Mouse lung, Mouse spleen, Mouse thymus, Rat lung, Rat liver, THP-1
Cellular Location: Cytoplasm, Nucleus
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.