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SIAH1 Rabbit mAb - A23247

SIAH1 Rabbit mAb - A23247

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SIAH1 Rabbit mAb

Sizes: 20µl, 100µl

Catalogue Numbers: A23247-20, A23247-100

Citations, Manuals and SDS Available upon request.

Background: This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Synonyms: BURHAS; SIAH1A; SIAH1

GeneID: 6477

Swiss-Prot: Q8IUQ4

Reactivity: Human, Mouse, Rat

Tested Applications: ELISA, WB, IHC-P, IF/ICC

Calculated Molecular Weight: 31kDa

Observed Molecular Weight: 31kDa/35kDa

Immunogen: A synthesized peptide derived from human SIAH1.

Immunogen Species: Human

Host: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.

Research Areas: Cell Biology Developmental Biology, Apoptosis, Ubiquitin, Ubiquitin-Proteasome Signaling Pathway, Neuroscience, Neurodegenerative Diseases, Dopamine Signaling in Parkinson's Disease

Recommended Dilutions: WB: 1:1000 - 1:5000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200

Modifications: Unmodified

Conjugate: Unconjugated

Cellular Location: Cytoplasm, Nucleus

Positive Samples: HeLa, 293F, Mouse liver

Keywords: sc-5505, sc-5506, sc-5504, sc-22765, hSIAH1, HUMSIAH, Seven in absentia homolog 1, Siah 1, Siah 1a, SIAH1, SIAH1A, siah E3 ubiquitin protein ligase 1, E3 ubiquitin-protein ligase SIAH1, RING-type E3 ubiquitin transferase SIAH1, seven in absentia homolog 1, siah-1a, Q8IUQ4, 6477, sc5505, sc 5505, sc5506, sc 5506, sc5504, sc 5504, sc22765, sc 22765

Symbol: SIAH1

Category: Monoclonal Antibodies

Research Use Only