
SIAH1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A23247-20, A23247-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Synonyms: BURHAS; SIAH1A; SIAH1
GeneID: 6477
Swiss-Prot: Q8IUQ4
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Calculated Molecular Weight: 31kDa
Observed Molecular Weight: 31kDa/35kDa
Immunogen: A synthesized peptide derived from human SIAH1.
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Cell Biology Developmental Biology, Apoptosis, Ubiquitin, Ubiquitin-Proteasome Signaling Pathway, Neuroscience, Neurodegenerative Diseases, Dopamine Signaling in Parkinson's Disease
Recommended Dilutions: WB: 1:1000 - 1:5000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Nucleus
Positive Samples: HeLa, 293F, Mouse liver
Keywords: sc-5505, sc-5506, sc-5504, sc-22765, hSIAH1, HUMSIAH, Seven in absentia homolog 1, Siah 1, Siah 1a, SIAH1, SIAH1A, siah E3 ubiquitin protein ligase 1, E3 ubiquitin-protein ligase SIAH1, RING-type E3 ubiquitin transferase SIAH1, seven in absentia homolog 1, siah-1a, Q8IUQ4, 6477, sc5505, sc 5505, sc5506, sc 5506, sc5504, sc 5504, sc22765, sc 22765
Symbol: SIAH1
Category: Monoclonal Antibodies
Research Use Only