4-1BBL/CD137L Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A3386-20, A3386-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Synonyms: CD137L; TNLG5A; 4-1BB-L; 4-1BBL/CD137L
GeneID: 8744
Swiss-Prot: P41273
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 27kDa
Observed Molecular Weight: 27kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 155-254 of human 4-1BBL/CD137L (P41273).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Cancer, Cell Biology Developmental Biology, Apoptosis, Growth factors, Immunology Inflammation, Cytokines, Cell Intrinsic Innate Immunity Signaling Pathway
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, Raji, SH-SY5Y, Mouse lung, Mouse brain, Rat lung
Cellular Location: Membrane, Single-pass Type II Membrane Protein
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.