67kDa Laminin Receptor Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A5968-20, A5968-100
Citations, Manuals and SDS Available upon request.
Background: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Synonyms: SA; LBP; LRP; p40; uS2; 67LR; ICAS; lamR; 37LRP; LAMBR; LAMR1; LRP/LR; LBP/p40; NEM/1CHD4; 67kDa Laminin Receptor
GeneID: 3921
Swiss-Prot: P08865
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 33kDa
Observed Molecular Weight: 45kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 196-295 of human Laminin Receptor (P08865).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IF/ICC: 1:50 - 1:200
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cell Adhesion, Cytoskeleton, Intermediate Filaments, Extracellular Matrix, Neuroscience, Neurodegenerative Diseases, Cardiovascular, Angiogenesis
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: PC-12, A-549, BxPC-3, Raji, RAW264.7, Rat pancreas
Cellular Location: Cytoplasm, Cytosol, Cytosolic Ribosome, Extra Cellular Exosome, Nucleoplasm, Nucleus, Plasma Membrane
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.