ABCA1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A21976-20, A21976-100
Citations, Manuals and SDS Available upon request.
Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency.
Synonyms: TGD; ABC1; CERP; ABC-1; HDLDT1; HPALP1; HDLCQTL13; ABCA1
GeneID: 19
Swiss Prot: O95477
Tested Applications: ELISA, IF/ICC
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 254kDa
Observed Molecular Weight: Refer to figures
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1170-1350 of human ABCA1 (NP_005493.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: IF/ICC: 1:50 - 1:200
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Lipid Metabolism, Cholesterol Metabolism, Neuroscience, Cell Type Marker, Cardiovascular, Heart, Lipids, Cardiovascular diseases, Heart disease, Astrocyte marker
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Membrane, Multi-pass Membrane Protein,
Keywords: 19, ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD, ATP binding cassette subfamily A member 1, ATP-binding cassette sub-family A member 1, ATP-binding cassette transporter A1, ATP-binding cassette, sub-family A (ABC1), member 1, cholesterol efflux regulatory protein, membrane-bound, O95477, ATP Binding Cassette Subfamily A Member 1, ATP-Binding Cassette, Sub-Family A (ABC1), Member 1, Cholesterol Efflux Regulatory Protein, ATP-Binding Cassette Sub-Family A Member 1, ATP-Binding Cassette Transporter A1, ATP-Binding Cassette Transporter 1, ATP-Binding Cassette 1, Tangier Disease, Membrane-Bound, ABC 1
Symbol: ABCA1
Category: Monoclonal Antibodies
Research Use Only