ABCG2 Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB11935-50, MB11935-100
Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Swiss-Prot: Q9UNQ0
Host: Rabbit
Reactivity: Human
Applications: WB
All Applications: WB: 1/500-1/1000
Background: ABCG2 confers resistance for a variety of chemotherapeutic agents, including anthracyclines, mitoxantrone, bisantrene and topotecan. Play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
Purification and Purity: Affinity Purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of BCRP/ABCG2 in HepG2, U251, HL-60Lysates using ABCG2 antibody.
Bioworld Molecular Weight: Calculated MW: 72 kDa; Observed MW: 72 kDa
Specificity: IgG
Alternative Name: ABCG2; ABCP; BCRP; BCRP1; MXR; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; CD338
Immunogen: A synthetic peptide of human BCRP/ABCG2
Conjugate: Unconjugated
Modification: Unmodified