
ACE1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A11357-20, A11357-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes an enzyme involved in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This angiotensin converting enzyme (ACE) also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored membrane proteins in spermatozoa. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer's disease. Regulation of the homologous ACE2 gene may be involved in progression of disease caused by several human coronaviruses, including SARS-CoV and SARS-CoV-2. Alternative splicing results in multiple transcript variants encoding both somatic (sACE) and male-specific testicular (tACE) isoforms.
Synonyms: DCP; ACE1; DCP1; CD143
GeneID: 1636
Swiss Prot: P12821
Tested Applications: ELISA, WB, IP
Reactivity: Mouse, Rat
Calculated Molecular Weight: 150kDa
Observed Molecular Weight: 170kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1200-1306 of human ACE1 (P12821).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IP: 0.5μg-4μg antibody for 400μg-600μg extracts of whole cells
Research Areas: Cancer, Signal transduction, Cell biology developmental biology, Ubiquitin, Endocrine metabolism, Immunology inflammation, CDs, Stem cells, Hematopoietic progenitors, Cardiovascular, Blood, Serum proteins, Hypoxia
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Mouse lung, Mouse kidney, Rat kidney
Cellular Location: Cell Membrane, Cytoplasm, Secreted, Single-pass Type I Membrane Protein,
Keywords: ACE, ACE1, CD143, DCP, DCP1, angiotensin I converting enzyme, angiotensin-converting enzyme|CD143 antigen|angiotensin I converting enzyme (peptidyl-dipeptidase A) 1|angiotensin converting enzyme, somatic isoform|carboxycathepsin|dipeptidyl carboxypeptidase 1|dipeptidyl carboxypeptidase I|kininase II|peptidase P, P12821
Symbol: ACE
Category: Monoclonal Antibodies
Research Use Only